Cardiac Remodeling

Cardiac remodeling also known as ventricular remodeling is defined as altered genomic expression leading to molecular, cellular and interstitial changes which cause changes in shape, size, structure and function of the heart. Cardiac myocyte is the major cell involved in cardiac remodeling. The underlying cause for cardiac remodeling may be physiological or pathological remodeling, cardiac load, hemodynamic load, neurohumoral activation. Chronic hypertension, valvular heart disease, congenital heart disease may also lead to cardiac remodeling. Cardiac remodeling may further lead to myocardial necrosis and disproportionate thinning of heart.